Christina Applegate, a renowned actress, has faced multiple health challenges, including Multiple Sclerosis, which forced her to leave the entertainment industry. Despite these challenges, she has maintained a strong support system through her husband and daughter. She also underwent a double mastectomy in 2017.

At the age of 49, Applegate announced her diagnosis of Multiple Sclerosis (MS) in August 2021. Because of the ailment, Applegate had to alter his work methods and deal with physical difficulties on the job. The actress found out about her condition while filming the last season of “Dead to Me,” yet she kept playing the part.